Viola Davis as Professor Annalise Keating, Esquire: A high-profile defense attorney, teaching a class at Middleton University.[1]
Billy Brown as Detective Nate Lahey: Annalise's lover who tries to prove Sam's involvement in the Lila Stangard murder and the main suspect in Sam's murder.[2]
Alfred Enoch as Wes Gibbins: A student recently accepted off the wait list who later has a relationship with Rebecca.[3]
Jack Falahee as Connor Walsh: A law student seen as ruthless and somewhat narcissistic by his peers.[3]
Katie Findlay as Rebecca Sutter: Wes' mysterious neighbor who becomes a suspect in the murder of Lila Stangard.[4]
Aja Naomi King as Michaela Pratt: An ambitious student who wants to be successful like Annalise.[5]
Matt McGorry as Asher Millstone: One of Annalise's students who comes from a privileged background.[6]
Karla Souza as Laurel Castillo: An idealistic student who later has a relationship with Frank.[3]
Charlie Weber as Frank Delfino: An employee of Annalise's firm who is not a lawyer but handles special duties requiring discretion [7]